Redox Signaling Molecules

The most abundant molecules of life


The human body is constantly working to maintain cellular health. It does this by balancing reactive molecules to rid the body of harmful components and to clean up the oxidative stress and free radical damage that occur at the cellular level. When these reactive molecules are in the proper balance, the immune system and healing process function at their optimal level.
Volumes of research from independent scientists around the world confirm the vital nature of Redox Signaling to cell health. And every day more research and published articles are appearing about Redox Signaling, making it one of the fastest growing research fields in science.

What are Redox Signaling molecules?

Redox Signaling is a function that is central to all life on the planet. Redox Signaling molecules are created within every cell of the body, and are vital to the immune system and to cellular healing mechanisms. Redox Signaling molecules are so essential to life that without them, you would die within seconds.
A proper supply of Redox Signaling molecules enables the normal cellular healing process: damaged, dysfunctional cells fading away and healthy, vibrant cells taking over. .

How do these molecules work?

Redox Signaling molecules are classified into two groups: Reactive Oxygen Species and Reduced Species. The Reactive Oxygen Species arms the immune system, the Reduced Species activates antioxidants. A careful, homeostatic balance between these two species is maintained in all cells and tissues. When a problem or damage occurs, this balance is disturbed, and this imbalance sends a signal to cause the cells and tissues to defend and repair themselves, thus restoring healthy balance.

Why is Redox signaling so important?

Both the internal and external factors such as stress, toxic chemicals, bacterial infections, poor nutrition etc affect our health in an adverse way. This causes significant cellular damage and a reduction in Redox signaling molecules. Without an adequate supply of Redox signaling molecules the antioxidants and immune system are unable to function effectively, leading to a vast range of health ailments.

Cells are damaged by factors like sunlight, environmental pollution, toxins, chemicals, infections and other irritants. Damaged cells build up oxidants or free radicals. As a part of the Redox signaling process, the activator molecules trigger the antioxidants that neutralize the free radicals and maintain a balance of oxidative molecules in the body. Also the signaling molecules ensure that the immune system and cellular communication is functioning at optimum levels. A lack of Redox signaling molecules disrupts this entire process – the balance of activated oxygen molecules is destroyed, leading to cellular damage and other health ailments.

As described by Dr. Naidu...
Life is an extraordinary REDOX program designed to capture, store, and expend energy through the reorganization of chemical bonds. Plants and animals require a continuous flow of chemicals that refill the spent molecules that regulate our cells and keep them in balance. Life is dependent on these complex energy transformations – all living organisms require energy for survival, growth and multiplication. On earth we have two types of energy production: some living systems derive their energy from sunlight, like plants, while other living systems, like animals, use the organic material created by plants as their source of energy (cows, for example, eat grass). Both types of energy require specialized adaptations to use these energy sources and these are called REDOX reactions. When the balance of these REDOX reactions inside our cells is disturbed chronic disease and aging can occur. Various external influences can cause these imbalances within like diet, toxins, pollution, excessive sun exposure, bacteria, viruses and more. Dr. Naidu describes in great detail how systems of the body are affected by this type of imbalance in our cells.

Protect . Repair .  Replace

We live and die at the cellular level. Every aspect of our health begins with the condition of our cells. Cells that are damaged, stressed, and slow to recover diminish the body’s ability to maintain a healthy balance. Cells that protect and heal themselves quickly result in improved health.

The health of our cells determines the health of our bodies. Our cells are designed first to protect themselves, second to repair any damage that does occur, and finally to replace a cell that experiences irreparable damage. The cell’s ability to do this depends on how quickly and efficiently it can communicate, both inside and outside the cell

The possibility of stabalizing redox signaling molecules and using them as bio-agents, non-toxic agents inside of our body is phenominal. It will be the future technology… that will affect almost all areas of health science. This technology has the potential of spearheading some of the greatest advances of health in the world. - Dr.Gary Samuelson

VO2 Testing Results with ASEA

VO2 Testing Results with ASEA

This document report provides the results of VO2max Athletic Endurance Testing performed on 17 Athletes from June to July 2009 who took ASEA on a regular basis. Learn More Experimental Methods for VO2max testing: Seventeen (17) Athletes performed a VO2max test where heart rate (HR), oxygen intake (VO2), Carbon Dioxide outflow (VCO2) and Ventilatory Threshold (VT explained below) were measured during a standard professionally administered VO2max endurance test. Athletes were selected based on their answers on a signed questionnaire that assessed their physical condition and commitment to follow the rules. In order to be qualified, each athlete affirmed that they typically work out rigorously an average of more than 5 hours per week, ate a healthy diet during the test period and was adequately hydrated before each test. Each athlete agreed to follow the rules including maintaining their normal daily routines during the test period and faithfully drinking ASEA during the 14 day test period; they abstained from drinking ASEA for at least a week before the initial baseline testing. The athletes took the baseline test the week of June 15 before taking ASEA. The final test, after taking ASEA (4 oz. per day) for more than 14 days, was done between June 27 and July 9. Each athlete drank 8 oz of ASEA immediately before taking the final test. The VO2max tests were performed on a CardioCoach® system by technicians having more than 5 years experience of administering VO2max tests on this system. The results were analyzed using standard statistical methods for determining Ventilatory Threshold (VT). Detailed explanations are given in the Results section. During the baseline VO2max test, the power output level of the athlete was recorded (the resistance level of the cycle or the speed and incline of the treadmill). This information was used to repeat the same power levels during the final test, making the final test, as far as power output, a repeat of the initial baseline test. If the athlete’s endurance allowed, the test then would be continued at a higher power output until VO2max was detected. This experiment is designed to allow comparison between the performance of a varied group of athletes on the VO2max test before they took ASEA to their performance on the same test after taking ASEA for more than 14 days and directly before testing. At least 15 athletes were needed in order to have a broader statistical base to measure significant trends. Even though this testing did not have a control group, there was a broad enough base to establish significant trends that can be further studied and verified by controlled double-blind tests on elite groups later on. Physiological Explanation of VT Endurance Measurements: For this experiment, the focus was placed on measuring Ventilatory Threshold (VT), which is widely recognized as a better and more accurate way to measure endurance and power output capacity than VO2max itself. The VT can be measured by comparing the volume of oxygen intake (VO2) to the volume of Carbon Dioxide exhaled (VCO2). As the muscles put out more power, their demand for oxygen from the blood grows proportionally to the amount of waste CO2 they expel into the blood. This is reflected in the VO2 and VCO2 measurements. The body can be thought of as a machine: oxygen (O2) goes into the lungs, passes into the blood where it is pumped into the muscle tissues. There it is combined with sugars and fats to produce the energy needed to sustain the power output. The waste products of aerobic energy production include carbon dioxide (CO2). CO2 is passed back out of the tissues into the lungs where it is then expelled. The amount of O2 going in during aerobic exercise should be directly proportional to the CO2 expelled; this is seen on a graph comparing VCO2 to VO2 as a line. There comes a point, however, during the VO2max test that the power output of the muscles exceeds the ability of the lungs and heart to supply the needed oxygen. At this point an anaerobic process inside the muscle tissues begins to produce energy (energy without oxygen) in order to supply the energy deficit. The waste products of this process include lactic acid and an additional amount of CO2. This anaerobic CO2 waste, combined with the aerobic CO2 waste can be measured as a much increased VCO2 measurement relative to the VO2. This point (VT) can be seen on the VCO2 vs. VO2 graph as a “kink” as the volume of CO2 being expelled goes quickly up to a higher level. VT is defined as the point where VCO2 starts its steeper incline. Thus VT marks the end of pure aerobic energy producing process and the beginning of a mixture of aerobic and anaerobic energy producing processes. This can also be measured with a sharp increase of lactic acid in the blood (usually denoted LT, Lactic Threshold). In this experiment LT is not measured. As lactic acid builds up in the tissues, it inhibits the ability of the tissues to absorb oxygen efficiently, making the aerobic process less efficient. At the Anaerobic Threshold (AT), the build-up of lactic acid begins to spiral up out of control. A few minutes after AT, the carbohydrate supply also runs out and the muscle tissue fails to function. This point of complete exhaustion typically comes several tens of seconds after VO2max, (the point where the body is taking in the maximum amount of O2 possible). VO2max depends on a lot of genetic factors such as lung capacity, heart capacity and the efficiency of the air-blood interface to exchange O2 and CO2 in the lungs as well as the efficiency of the blood-tissue interface in the muscles. Normally VO2max will only significantly increase if lung or heart capacity increases due to long periods of strenuous exercise. VT, on the other hand, is a measure of how much power an athlete is able to sustain at his peak aerobic efficiency. VT can be increased if the blood-air interface in the lungs or blood-tissue interface becomes more efficient in transporting oxygen or getting rid of CO2 and lactic acid. Thus VT is a parameter that it makes sense to target for increase in athletic training. Results of the VO2max testing: The results of the test are presented in summary form with one specific example to illustrate measurements taken and the trends. Average Heart Rate (HR), Average VT, Average VO2max and Average Time to achieve VO2max are reported. Due to experimental error (a loose breathing mask, perhaps), the results for two athletes had to be removed from the averages for VT and VO2max (averaged over 15 athletes). Averages for Heart Rate and Total Time are based on all 17 athletes. Example of results for one athlete As an illustration of the trends seen, one athlete was selected that provided an easily visible example of the trends. His baseline VO2max score was 61.7 (close to the average) before ASEA and increased to 68.1 after ASEA, this was an exceptional increase possibly related to a combination other improvements. His Heart Rate (HR) also was lower during the final test, as evident in the graph (Average HR went from 133 to 121 bpm [beats per minute] over the comparable region).

Also plainly seen on the graph is the difference in the Time to achieve VO2max (the point where the HR graph-line ends). His final VO2max test (with ASEA) ran almost 4 minutes longer than his baseline test even at the highest power output. Below is shown his VCO2 vs. VO2 graph illustrating the clear “kink” in the data that defines his VT before (diamonds) and after (triangles) ASEA. He achieved VT at 376 seconds into the test on his baseline test. After ASEA,VT happened at 498 seconds, a more than 30% increase. This is much larger than the uncertainty in the difference of his power output between the two tests. Also seen is the trend that VCO2 is increasing at a milder rate after taking ASEA, both before and after VT.

In over 70% of the athletes, similar trends were seen, especially in the VT. Summary of Results The following table gives a summary of the results over all tested athletes as already explained. There is a statistical variance of about 3% on the VT averages; similar uncertainties should apply to all these averages.

Heart Rate is only measured over comparable regions, as to only compare heart rates at similar power output. An interesting aside, there was no difference in the average heart rate (taken over all athletes) in the interval preceding VT before and after ASEA was taken. Observations and Conclusions Based on Results: There is a clear and unequivocal trend in the VO2max data. Based on the data, about 70% of the athletes that try ASEA should experience the ability to maintain a higher power output without crossing the Ventilatory Threshold (VT) that instigates fatigue, allowing them to go longer at the same power burn or to operate at a higher power burn than possible before ASEA. This is based on the most salient feature of the data–the extension of time at similar power levels before the VT and VO2max fatigue-related thresholds. These results deserve more careful investigation and verification. Since 14 days do not give the body enough time to increase lung capacity or cardiovascular capacity, it seems reasonable to conclude that these trends may be more indicative of short range increases in the oxygen-transfer efficiency caused by the ingestion of ASEA, either at the lungs or in the tissues. It may also be indicative of an increased efficiency in ridding the body of excess lactic acid. This would indicate that ASEA would be most effective taken directly before and after exercise. Learn More

Believe – Belong – Become

Principle Filled & Purpose Driven Despite being a relatively young company (officially launched Sept 10th 2010) ASEA is committed to developing a principle and purpose driven culture. ASEA has NOT taken the common shortcuts that some Network Marketing companies are tempted to take. This includes giving top leaders “sweetheart” deals for joining the company or even worse giving them special positioning in the compensation structure. This unfair and un-principled behavior has proven the downfall of several companies over the last few years.The ASEA product and opportunity is so strong it gives us the courage to be truthful and transparent. We do not need to hype or over exaggerate. We do not have to bribe or persuade. Most importantly everything we do is focused on building long term sustainable growth and the next great legacy company in Network Marketing.Maintain P over E While Driving Up C At ASEA, we stress an important concept that demonstrates the importance of keeping “motivation for and commitment to” Ego and Economics in check versus “motivation for and commitment to” principles and purpose. We believe, that for long term success, our “P” score must always remain higher than our “E” score. At the same time we strive to increase our Capacity and become the best that we can be. Learn more Believe – Belong – Become We offer entrepreneurs a place where they can believe in a product that is real and backed by patented science and thousands of lives changed. We create an environment where they can belong to a movement and a cause that is filled with a tremendous sense of purpose. And finally we offer the support and training necessary for people to become all they can be, for some, to become the leader that people are looking for. If that is you, I looking forward to speaking with you. Learn more

Redox and Oxidative Stress

Sports and Oxidative Stress

Studies show that intense exercise increases levels of free radicals and cellular oxidative stress.  This does not mean that you will be healthier if you stop exercising.  There is a net benefit to exercising.  And even some benefits to low levels of exercise-induced oxidative stress.  The body's natural antioxidant defenses, however, can easily be overwhelmed by intense exercise and the large amounts of free radicals created from increased cellular metabolism.  Both the weekend-warrior and the professional athlete alike are at risk from the destructive forces of free radicals.
Press here to Learn more.

What is Redox and Oxidative Stress?

The technical answer:

"Redox" is a scientific term that describes chemical reactions that involve the addition or reduction of electrons to molecules, thus altering oxidation numbers or "oxidation states."  Redox is shorthand for the reduction/oxidation reaction involved.  Disturbances in this normal redox state in the body can cause toxic effects due to the production of peroxides (yes, the same stuff in your medicine cabinet!) and free radicals that inflict molecular damage to proteins, DNA, and lipid membranes, in a process called "oxidative stress."  Oxygen itself is an exceedingly reactive element when unbound and is capable of forming a multitude of toxic free radicals.
Press here to Learn more.

The real-world answer:

The process by which our cells extract energy from food involves chemical reactions that leave some molecules missing an electron, making them unstable and very reactive.  This unstable molecule is called a free radical.  In the free radical's effort to restore its natural energy balance it will "steal" an electron from the first available source.  In the absence of adequate anti-oxidants, the free radical will steal an electron from healthy tissue such as DNA, your cellular membranes, or a host of other tissues you would prefer left intact.
Press here to Learn more.

The bottom line:

Cellular redox balance is maintained by varous complex chemical and enzymatic antioxidant defenses to free radicals.  When the body's redox balance is lost, harmful oxidative stress is caused.  Minimizing oxidative stress means minimizing cell degeneration and cellular damage, which is turn means better health.
Press here to Learn more.

Lifestyle Choices

Avoiding excessive intake of pro-oxidants such as smoke, excessive alcohol, exposure to noxious chemicals or ultraviolet light, are a good start in the quest to minimize oxidative stress.  The world in which we live, however, doesn't always cooperate with us.
Most fruits and vegetables contain antioxidants, and should be a part of your daily diet. And whenever possible avoid processed or preserved foods, and charred meats, which all can have negative oxidative effects on your body.
Press here to Learn more.

But Life Gets Busy...

It's no secret getting proper nutrition can be challenging in the best of circumstances. And who among us wants to worry if he or she is pushing too hard during exercise or play. Add to that, the increased nutritional demands on athletes and active people.  It is easy to find yourself behind in your body's nutritional needs.
Press here to Learn more.

The Best Defense

Nothing is better for health than a diet of whole, fresh foods rich in antioxidants, adequate hydration, and plenty of sleep.  Unfortunately, the reality is that the harder we work and play, the more we try to pack into our lives, the more our diet and sleep typically suffer. Proper supplementation can help you bridge the gap between a "perfect diet" and your diet, and help keep you at your optimal health and strength.
Press here to Learn more.

Factors that Increase Oxidative Stress

Intense exercise:

Three significant events or systems occur during exercise that combine to create increased oxidative stress loads.
1) Whole body oxygen consumption:  Exercise can demand a 10-20 fold increase in whole body oxygen consumption, and a staggering 100-200 fold increase in local muscle oxygen consumption.  Most of this oxygen is transformed to water, but 2-4% is converted into damaging free radicals.
2) Ischaemia-reperfusion:  This is a result of redistribution of blood away from our organs to our working muscles, which in turn leads to local muscle hypoxia (shortage of oxygen).  When intense exercise stops, a reoxygenation of your organs and local muscles takes place. This results in a burst of free radicals.
3) Auto-oxidation of catecholamines:  Rising levels of the stress hormones such as adrenaline and noradrenaline are normal during exercise.  Some of these hormones become oxidized and then create free radicals, which contributes to muscular fatigue during and after exercise.
Press here to Learn more.

Environmental Accelerants:

1) Excessive intake of pro-oxidants:  A pro-oxidant would include smoking, certain drugs, alcohol, additives/preservatives in foods, and exposure to industrial toxins from air pollution, ozone, and smog.
2) Ultraviolet light:  We all know that excessive sun causes our skin to age prematurely.  The reason behind this is oxidative stress from UV radiation.  Athletes and active people are at particular risk to over exposure of UV light.

Press here to Learn more.

Disease, Aging and Oxidative Stress

U.S. government funding for studies on antioxidants and disease conditions has more than doubled in the last year to almost 300.  We now know that oxidative stress is a compounding factor in neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS, Huntington's disease, and diabetic neuropathy.  Oxidative stress is also a factor in cataracts, stroke, renal disease and arteriosclerosis.
The Free Radical Theory of Aging states that, over time, mitochondria accumulate damage to their genetic material.  The result is progressively fewer mitochondria capable of providing sufficient energy for optimal cell function.  This ultimately leads to cell death and physical aging.  Many of the diseases associated with oxidative stress are diseases that manifest earlier in people with higher oxidative stress loads or a poor redox balance.
Press here to Learn more.

Redox Signaling Molecules – Oxidative Stress PREVENTION

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.

ASEA Redox Signaling Molecules – Oxidative Stress PREVENTION

For those who really want the “science” can’t get more scientific than googling pubmed.gov and searching Redox Signaling Molecules. pubmed.gov is an all database search for real scientific research from medical journals. What a chiropractor found out on pubmed.gov was that Redox Signaling Molecules activates antioxidants and boosts antioxidant protection, and that they are the basic detection when there is a problem in our cells to either kill microbes or to replace or repair that problem the cells involved and that redox signaling molecules are catalysts for all healing on the cellular level. So, it does not matter what  you call the health problem, if it has to do with a cell, then a redox signaling molecule will signal to our body to help that cell out. If we have a massive amount of these redox molecules when we drink a few ounces, it is like drinking an entire Napoleon’s army, coming to our body’s rescue.

Scientists who discovered the Krebs Cycle — the part that actually creates “energy” for our muscles to move — had not yet discovered redox signaling molecules were a FUNDAMENTAL part of that cycle — that was many years ago. But research NOW knows that  those 2 types of redox signaling molecules that are released at the end of each Krebs Cycle are the fundamental and foundational end product from that “cycle” that is taking place with every breath we take.

These molecules are working whether you feel it immediately or not if you do the research you will know that. Prevention is not something you see, but it prevents you from seeing something in the future you might wish you were not seeing. That is what the name means: PREVENTION.

Another way to test if ASEA Redox Signaling Molecules are “working:” find a chiropractor or alternative doctor who has an Oxidative Stress Machine. This machine measures the amount of formaldehydes that are formed in your breath, you blow through it, and formaldehydes are formed. This is done through oxidative stress – the machine measures your overall inflammation throughout your body. Test before ASEA and then 24 hours after ASEA.

Normally if someone takes the right supplements they will usually see an improvement in oxidative stress 3-6 weeks, that is usually 5-15%, but we found that ASEA had a 6% difference in 24 hours.

One person’s oxidative stress level before he ever tried ASEA was 551. Twenty four hours after taking ASEA for the very first time he was 519 — that is a 6% reduction of inflammation in 24 hours after 6-8 ounces in 24 hours. I will follow up with an actual recording of his testimony in the near future.

Inflammation is a chronic health problem for the majority of people nowadays. ASEA signals the cells to reduce inflammation dramatically. This testing is an objective and measurable test.

Want to Achieve Similar Results Click Here

So the ASEA redox signal molecules get us back up to where we were when we were young. People start looking and acting like they would have in their youth.

I have had more progress in 4 months than in the last 4 years by using ASEA. I have a moral obligation in letting people know it can help them. If I don’t tell someone about it, I am accountable. People are suffering because they don’t know about ASEA Redox Signaling Molecules.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.

Natural Eradication of Heart Failure

Tens of millions of people worldwide suffer from heart failure, which results in shortness of breath, edema and fatigue. The number of heart failure patients has tripled over the last few decades. The epidemic spread of this disease is largely due to the fact that, until now, the causes of heart failure have been insufficiently, or not at all, understood. In some cases, heart failure is the result of a heart attack; in most cases, however, such as with cardiomyopathies, heart failure develops without any prior cardiac event.

Learn more about Cellular Health

Conventional medicine is largely confined to treating the symptoms of heart failure. Diuretic drugs are given to flush out the water that is retained in body tissues because of the weak pumping function of the heart. However, they also flush out water-soluble micronutrients, thereby causing additional health problems. The still insufficient understanding of the causes of heart failure explains the unfavorable prognosis of this disease. Five years after a heart failure condition is diagnosed, only 50% of the patients are still alive. For many patients with heart failure, a heart transplant operation is the last resort. Most heart failure patients, however, die without ever having the option of such an operation.

Cellular Medicine provides a breakthrough in the understanding of the causes, prevention and adjunct treatment of heart failure. The primary cause of heart failure is a deficiency of vitamins and other essential nutrients providing bioenergy to the millions of heart muscle cells. These cells are responsible for the contraction of the heart muscle and for the optimum pumping of blood into circulation. Deficiencies of vitamins and other essential nutrients impair the pumping performance of the heart, resulting in shortness of breath, edema and fatigue.

Scientific research and clinical studies have already documented the particular value of carnitine, coenzyme Q-10 and other essential nutrients. These components of Dr. Rath’s Cellular Health recommendations help improve the function of millions of heart muscle cells, the pumping function of the heart itself and, thereby, the quality of life of heart failure patients.

The Fatal Consequences of Incomplete Treatment of Heart Failure

For decades, the focus of conventional medicine on diuretics and other symptom-oriented pharmaceutical drugs has prevented the discovery of the true cause of heart failure. Moreover, the conventional treatment of heart failure patients shows how the lack of understanding about the root cause of a disease leads to a vicious cycle in which therapeutic measures worsen the health problem.
Today, we know that the chronic deficiency of essential cellular nutrients in heart muscle cells impairs the pumping function of the heart. This leads to impaired blood circulation in different organs of the body. For example, the kidneys remove excess water by filtering it from the blood into the urine. With impaired blood flow through the kidneys, water is retained in tissues and causes swelling (edema) of the legs, lungs and other parts of the body.
In order to eliminate edema, doctors prescribe diuretic medications. This measure starts a vicious cycle in the conventional therapy of heart failure. Diuretics remove water-soluble vitamins, such as vitamins C and B, and important minerals and trace elements from the body. Since vitamin deficiency is already the main cause of heart failure, diuretic medications further aggravate the disease.
Now we understand why the prognosis of heart failure is so unfavorable. The future therapy of heart failure is straightforward: the supplementation of vitamins and other essential cellular nutrients. If water has accumulated in a patient’s body, diuretics should be given. Irrespective of that, the daily supplementation of essential cellular nutrients must become an essential part of any heart failure therapy.
As a heart failure patient, you should talk with your doctor about these findings. A responsible physician will support this essential nutrient program.

to believe, to belong, and to become

Every human being has 3 basic needs: to believe, to belong, and to become. ASEA empowers its Associates to believe in a life-changing product, to belong to an organization driven by principles, and most importantly to become better people, professionally and personally.