Redox and Oxidative Stress

Sports and Oxidative Stress

Studies show that intense exercise increases levels of free radicals and cellular oxidative stress.  This does not mean that you will be healthier if you stop exercising.  There is a net benefit to exercising.  And even some benefits to low levels of exercise-induced oxidative stress.  The body's natural antioxidant defenses, however, can easily be overwhelmed by intense exercise and the large amounts of free radicals created from increased cellular metabolism.  Both the weekend-warrior and the professional athlete alike are at risk from the destructive forces of free radicals.
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What is Redox and Oxidative Stress?

The technical answer:

"Redox" is a scientific term that describes chemical reactions that involve the addition or reduction of electrons to molecules, thus altering oxidation numbers or "oxidation states."  Redox is shorthand for the reduction/oxidation reaction involved.  Disturbances in this normal redox state in the body can cause toxic effects due to the production of peroxides (yes, the same stuff in your medicine cabinet!) and free radicals that inflict molecular damage to proteins, DNA, and lipid membranes, in a process called "oxidative stress."  Oxygen itself is an exceedingly reactive element when unbound and is capable of forming a multitude of toxic free radicals.
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The real-world answer:

The process by which our cells extract energy from food involves chemical reactions that leave some molecules missing an electron, making them unstable and very reactive.  This unstable molecule is called a free radical.  In the free radical's effort to restore its natural energy balance it will "steal" an electron from the first available source.  In the absence of adequate anti-oxidants, the free radical will steal an electron from healthy tissue such as DNA, your cellular membranes, or a host of other tissues you would prefer left intact.
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The bottom line:

Cellular redox balance is maintained by varous complex chemical and enzymatic antioxidant defenses to free radicals.  When the body's redox balance is lost, harmful oxidative stress is caused.  Minimizing oxidative stress means minimizing cell degeneration and cellular damage, which is turn means better health.
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Lifestyle Choices

Avoiding excessive intake of pro-oxidants such as smoke, excessive alcohol, exposure to noxious chemicals or ultraviolet light, are a good start in the quest to minimize oxidative stress.  The world in which we live, however, doesn't always cooperate with us.
Most fruits and vegetables contain antioxidants, and should be a part of your daily diet. And whenever possible avoid processed or preserved foods, and charred meats, which all can have negative oxidative effects on your body.
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But Life Gets Busy...

It's no secret getting proper nutrition can be challenging in the best of circumstances. And who among us wants to worry if he or she is pushing too hard during exercise or play. Add to that, the increased nutritional demands on athletes and active people.  It is easy to find yourself behind in your body's nutritional needs.
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The Best Defense

Nothing is better for health than a diet of whole, fresh foods rich in antioxidants, adequate hydration, and plenty of sleep.  Unfortunately, the reality is that the harder we work and play, the more we try to pack into our lives, the more our diet and sleep typically suffer. Proper supplementation can help you bridge the gap between a "perfect diet" and your diet, and help keep you at your optimal health and strength.
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Factors that Increase Oxidative Stress

Intense exercise:

Three significant events or systems occur during exercise that combine to create increased oxidative stress loads.
1) Whole body oxygen consumption:  Exercise can demand a 10-20 fold increase in whole body oxygen consumption, and a staggering 100-200 fold increase in local muscle oxygen consumption.  Most of this oxygen is transformed to water, but 2-4% is converted into damaging free radicals.
2) Ischaemia-reperfusion:  This is a result of redistribution of blood away from our organs to our working muscles, which in turn leads to local muscle hypoxia (shortage of oxygen).  When intense exercise stops, a reoxygenation of your organs and local muscles takes place. This results in a burst of free radicals.
3) Auto-oxidation of catecholamines:  Rising levels of the stress hormones such as adrenaline and noradrenaline are normal during exercise.  Some of these hormones become oxidized and then create free radicals, which contributes to muscular fatigue during and after exercise.
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Environmental Accelerants:

1) Excessive intake of pro-oxidants:  A pro-oxidant would include smoking, certain drugs, alcohol, additives/preservatives in foods, and exposure to industrial toxins from air pollution, ozone, and smog.
2) Ultraviolet light:  We all know that excessive sun causes our skin to age prematurely.  The reason behind this is oxidative stress from UV radiation.  Athletes and active people are at particular risk to over exposure of UV light.

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Disease, Aging and Oxidative Stress

U.S. government funding for studies on antioxidants and disease conditions has more than doubled in the last year to almost 300.  We now know that oxidative stress is a compounding factor in neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS, Huntington's disease, and diabetic neuropathy.  Oxidative stress is also a factor in cataracts, stroke, renal disease and arteriosclerosis.
The Free Radical Theory of Aging states that, over time, mitochondria accumulate damage to their genetic material.  The result is progressively fewer mitochondria capable of providing sufficient energy for optimal cell function.  This ultimately leads to cell death and physical aging.  Many of the diseases associated with oxidative stress are diseases that manifest earlier in people with higher oxidative stress loads or a poor redox balance.
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Redox Signaling Molecules – Oxidative Stress PREVENTION

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.

ASEA Redox Signaling Molecules – Oxidative Stress PREVENTION

For those who really want the “science” can’t get more scientific than googling pubmed.gov and searching Redox Signaling Molecules. pubmed.gov is an all database search for real scientific research from medical journals. What a chiropractor found out on pubmed.gov was that Redox Signaling Molecules activates antioxidants and boosts antioxidant protection, and that they are the basic detection when there is a problem in our cells to either kill microbes or to replace or repair that problem the cells involved and that redox signaling molecules are catalysts for all healing on the cellular level. So, it does not matter what  you call the health problem, if it has to do with a cell, then a redox signaling molecule will signal to our body to help that cell out. If we have a massive amount of these redox molecules when we drink a few ounces, it is like drinking an entire Napoleon’s army, coming to our body’s rescue.

Scientists who discovered the Krebs Cycle — the part that actually creates “energy” for our muscles to move — had not yet discovered redox signaling molecules were a FUNDAMENTAL part of that cycle — that was many years ago. But research NOW knows that  those 2 types of redox signaling molecules that are released at the end of each Krebs Cycle are the fundamental and foundational end product from that “cycle” that is taking place with every breath we take.

These molecules are working whether you feel it immediately or not if you do the research you will know that. Prevention is not something you see, but it prevents you from seeing something in the future you might wish you were not seeing. That is what the name means: PREVENTION.

Another way to test if ASEA Redox Signaling Molecules are “working:” find a chiropractor or alternative doctor who has an Oxidative Stress Machine. This machine measures the amount of formaldehydes that are formed in your breath, you blow through it, and formaldehydes are formed. This is done through oxidative stress – the machine measures your overall inflammation throughout your body. Test before ASEA and then 24 hours after ASEA.

Normally if someone takes the right supplements they will usually see an improvement in oxidative stress 3-6 weeks, that is usually 5-15%, but we found that ASEA had a 6% difference in 24 hours.

One person’s oxidative stress level before he ever tried ASEA was 551. Twenty four hours after taking ASEA for the very first time he was 519 — that is a 6% reduction of inflammation in 24 hours after 6-8 ounces in 24 hours. I will follow up with an actual recording of his testimony in the near future.

Inflammation is a chronic health problem for the majority of people nowadays. ASEA signals the cells to reduce inflammation dramatically. This testing is an objective and measurable test.

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So the ASEA redox signal molecules get us back up to where we were when we were young. People start looking and acting like they would have in their youth.

I have had more progress in 4 months than in the last 4 years by using ASEA. I have a moral obligation in letting people know it can help them. If I don’t tell someone about it, I am accountable. People are suffering because they don’t know about ASEA Redox Signaling Molecules.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.

Natural Eradication of Heart Failure

Tens of millions of people worldwide suffer from heart failure, which results in shortness of breath, edema and fatigue. The number of heart failure patients has tripled over the last few decades. The epidemic spread of this disease is largely due to the fact that, until now, the causes of heart failure have been insufficiently, or not at all, understood. In some cases, heart failure is the result of a heart attack; in most cases, however, such as with cardiomyopathies, heart failure develops without any prior cardiac event.

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Conventional medicine is largely confined to treating the symptoms of heart failure. Diuretic drugs are given to flush out the water that is retained in body tissues because of the weak pumping function of the heart. However, they also flush out water-soluble micronutrients, thereby causing additional health problems. The still insufficient understanding of the causes of heart failure explains the unfavorable prognosis of this disease. Five years after a heart failure condition is diagnosed, only 50% of the patients are still alive. For many patients with heart failure, a heart transplant operation is the last resort. Most heart failure patients, however, die without ever having the option of such an operation.

Cellular Medicine provides a breakthrough in the understanding of the causes, prevention and adjunct treatment of heart failure. The primary cause of heart failure is a deficiency of vitamins and other essential nutrients providing bioenergy to the millions of heart muscle cells. These cells are responsible for the contraction of the heart muscle and for the optimum pumping of blood into circulation. Deficiencies of vitamins and other essential nutrients impair the pumping performance of the heart, resulting in shortness of breath, edema and fatigue.

Scientific research and clinical studies have already documented the particular value of carnitine, coenzyme Q-10 and other essential nutrients. These components of Dr. Rath’s Cellular Health recommendations help improve the function of millions of heart muscle cells, the pumping function of the heart itself and, thereby, the quality of life of heart failure patients.

The Fatal Consequences of Incomplete Treatment of Heart Failure

For decades, the focus of conventional medicine on diuretics and other symptom-oriented pharmaceutical drugs has prevented the discovery of the true cause of heart failure. Moreover, the conventional treatment of heart failure patients shows how the lack of understanding about the root cause of a disease leads to a vicious cycle in which therapeutic measures worsen the health problem.
Today, we know that the chronic deficiency of essential cellular nutrients in heart muscle cells impairs the pumping function of the heart. This leads to impaired blood circulation in different organs of the body. For example, the kidneys remove excess water by filtering it from the blood into the urine. With impaired blood flow through the kidneys, water is retained in tissues and causes swelling (edema) of the legs, lungs and other parts of the body.
In order to eliminate edema, doctors prescribe diuretic medications. This measure starts a vicious cycle in the conventional therapy of heart failure. Diuretics remove water-soluble vitamins, such as vitamins C and B, and important minerals and trace elements from the body. Since vitamin deficiency is already the main cause of heart failure, diuretic medications further aggravate the disease.
Now we understand why the prognosis of heart failure is so unfavorable. The future therapy of heart failure is straightforward: the supplementation of vitamins and other essential cellular nutrients. If water has accumulated in a patient’s body, diuretics should be given. Irrespective of that, the daily supplementation of essential cellular nutrients must become an essential part of any heart failure therapy.
As a heart failure patient, you should talk with your doctor about these findings. A responsible physician will support this essential nutrient program.

to believe, to belong, and to become

Every human being has 3 basic needs: to believe, to belong, and to become. ASEA empowers its Associates to believe in a life-changing product, to belong to an organization driven by principles, and most importantly to become better people, professionally and personally.

Natural Eradication of High Blood Pressure

Worldwide, several hundred million people suffer from high blood pressure. Of all cardiovascular health conditions, this is the single largest epidemic. The epidemic spread of this disease is largely due to the fact that, until now, the causes of high blood pressure have been insufficiently, or not at all, understood.

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Conventional medicine concedes that the causes of high blood pressure are unknown in over 90% of patients. The frequent medical diagnosis “essential hypertension” was established to describe high blood pressure conditions in which the causes remain unknown. Conventional, pharmaceutical-oriented medicine is confined to treating the symptoms of this disease. Beta-blockers, diuretics and other high blood pressure medications artificially lower the blood pressure (symptom-oriented approach) without correcting the primary underlying problem — a “spasm” of the blood vessel wall.

Modern Cellular Medicine provides a breakthrough in our understanding of the causes, prevention and adjunct treatment of high blood pressure. The main cause of high blood pressure is a chronic deficiency of essential nutrients in millions of artery wall cells. Among other functions, these cells are responsible for the availability of “relaxing factors” (nitric oxide), which decrease vascular wall tension and keep the blood pressure in normal range. The natural amino acid arginine, vitamin C and other components of Dr. Rath’s Cellular Health recommendations contribute to the optimum availability of these artery wall relaxing factors. In contrast, chronic deficiency of these essential nutrients can result in spasms and a thickening of the blood vessel walls, which can eventually elevate blood pressure.

Scientific research and clinical studies
have documented the value of vitamin C, magnesium, coenzyme Q-10, arginine and other essential nutrients in helping to normalize high blood pressure conditions. Dr. Rath’s Cellular Health recommendations comprise select essential nutrients that are needed for the optimum functioning of vascular wall cells and, thereby, contribute to preventing high blood pressure and helping reverse existing high blood pressure conditions.

All these nutrients are components of my Cellular Health recommendations:

Arginine, the natural amino acid, splits off an artery wall “ relaxing factor,” a small molecule called nitric oxide. Nitric oxide increases the elasticity of the artery walls and helps to normalize high blood pressure.

Vitamin C increases the production of prostacycline, a small molecule that not only relaxes the blood vessel walls, but also keeps blood viscosity at optimum levels.

Magnesium, “nature’s calcium antagonist,” is essential for an optimum mineral balance in the blood vessel wall cells. Optimum mineral balance is a precondition for the relaxation of the artery walls.

Lysine and proline help protect the artery walls and prevent the development of atherosclerotic deposits. This important mechanism was discussed in Chapters Two and Three of this book in detail. Since atherosclerosis is intertwined with high blood pressure, these ingredients are also essential for preventing and correcting this health condition.
All these nutrients are components of my Cellular Health recommendations.

Natural Eradication of Diabetes

Worldwide, more than 100 million people suffer from diabetes. Diabetic disorders have a genetic background and are divided into two types: juvenile and adult. Juvenile diabetes is generally caused by a genetic defect that leads to an insufficient production of insulin in the body and requires regular insulin injections to control blood sugar levels. The majority of diabetic patients, however, develop this disease as adults. Adult forms of diabetes also have a genetic background. However, the causes that trigger the outbreak of the disease in these patients at any stage in their adult lives have been unknown. It is, therefore, not surprising that diabetes is yet another disease that is still growing on a global scale.
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Conventional medicine is confined to treating the symptoms of adult diabetes by lowering elevated blood levels of sugar. However, cardiovascular disease and other diabetic complications occur even in those patients with controlled blood sugar levels. Thus, lowering blood sugar levels is a necessary, but incomplete, treatment of diabetic disorders.
Modern Cellular Medicine now provides a breakthrough in our understanding of the causes, prevention and adjunct treatment of adult diabetes. The primary cause of adult onset diabetes is a long-term deficiency of certain vitamins and other essential nutrients in the millions of cells in the pancreas (the organ that produces insulin), the liver and the blood vessel walls, as well as other organs.
On the basis of an inherited diabetic disorder, deficiencies of vitamins and other essential nutrients can trigger a diabetic metabolism and the onset of adult diabetes. Conversely, the optimum intake of vitamins and other ingredients in Dr. Rath’s Cellular Health recommendations can help prevent the onset of adult diabetes and help correct existing diabetic conditions and its complications.
Scientific research and clinical studies have documented the particular value of vitamin C, vitamin E, certain B vitamins, chromium and other essential nutrients in helping to normalize a diabetic metabolism and prevent cardiovascular disease.
Diabetes is a particularly malicious metabolic disorder. Circulatory problems and clogging can occur in virtually any part of the 60,000-mile-long blood vessel pipeline.

How Diabetic Cardiovascular Disease Develops

The key to understanding cardiovascular disease in diabetics is understanding the similarity in the molecular structure of vitamin C and sugar (glucose) molecules. This similarity leads to metabolic confusion with severe consequences:
The cells of our blood vessel walls contain tiny biological pumps specialized for pumping sugar and — at the same time — vitamin C molecules from the bloodstream into the blood vessel wall. In a healthy person, these pumps transport an optimum amount of sugar and vitamin C molecules into the blood vessel wall, enabling normal function of the wall and, thus, preventing cardiovascular disease.
Because of the high sugar concentration in the blood, the sugar and vitamin C pumps are overloaded with sugar molecules. This leads to an overload of sugar and, at the same time, to a deficiency of vitamin C inside the blood vessel walls. The consequence of these mechanisms is a thickening of the walls throughout the blood vessel pipeline, which puts organs at risk for infarctions.
The optimum daily intake of selected cellular nutrients — in particular vitamin C — helps to restore the balance between vitamin C and sugar metabolism inside the cells of the pancreas, blood vessel walls and other organs.

Natural Eradication of Cancer

All human cells are surrounded by collagen fibres and connective tissue. In order to grow and expand, healthy cells need to break down this extra-cellular barrier that confines them. This process is essential for life and for this reason, cells produce and secrete various enzymes that digest connective tissue components, including collagen and elastin.
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It is important that these enzymes, called matrix metalloproteinases or MMPs, be regulated by sets of activators and inhibitors so that the integrity of the connective tissue is never compromised.
Excessive disintegration of connective tissue accompanies pathology and once this disintegration occurs, infectious cancer cell microbes (including viruses) can invade tissues. In extreme cases, such as in cancer, the excessive production of digestive enzymes and the disintegration of collagen and connective tissue by cancer cells are the dangerous mechanisms by which these cells invade and spread to other organs.
In his Cellular Health Series book "Cancer", Dr. Rath documents his scientific discovery that certain nutrients, including L-lysine, are powerful natural inhibitors of collagen-digesting enzymes. It is this discovery that has put Matthias Rath, Inc. on the path to defeating this devastating disease.

The Spread of Cancer Can Be Controlled

In the laboratory at Matthias Rath, Inc. scientists have conducted research with live cells to provide answers to various scientific questions. Once they understood the mechanism by which cancer cells metastasized, there was one critical question that the Matthias Rath Inc. researchers sought to answer: How could they naturally inhibit the invasion of cancer cells through collagen and connective tissue in a way that would enhance the body’s own capacity for managing disease?
In seeking this answer, the researchers designed an experiment so that they could first investigate the ability of cancer cells to digest through a collagenous matrix and then develop a method to control it. For this purpose, the researchers used specific vials that included partitions made of collagenous material similar to that which surrounds cells in the body. In the upper chamber of some vials, they incubated cancer cells with nutritive agents. In the upper chamber of other vials, they incubated cancer cells without nutritive agents. Afterwards, the researchers were able to determine which group of cancer cells was able to digest the collagen membrane and migrate to the lower chamber.
The results of the experiment were remarkable. A simple combination of nutrients was able to stop cancer cells from invading the collagen matrix!
The most powerful nutrient combination contained vitamin C, the amino acids L-lysine and L-proline, and a polyphenol fraction of green tea known as Epigallocatechin Gallate (EGCG).